Why Artilysin®: Breakthrough Against Bacteria

We Are Microbiome

The human microbiome consists of 10-100 trillion symbiotic microbial cells, primarily in the gut. Microbes living in and on the human body outnumber human cells by a ratio of 1.3 to 1, with a total mass of about 1-3% of body weight – amounting to 0.6-1.8 kg in a 60-kg individual.

Beyond Our Genes

Genetically, the microbiome far surpasses human diversity. While the human genome consists of approximately 22,000 genes, the gut microbiome alone contains an estimated 3.3 million. While human genomes are 99.9% identical from person to person, microbiomes can differ by 80-90%.

We Are Not Alone

For years, the human body was thought to function as an isolated system. Yet, without the trillions of microbes we coexist with, essential processes would be compromised: digestion, hunger regulation, and immune function all depend on this delicate balance.

Rethinking Sterilization

Is it really wise to eradicate such a complex system with antibiotics, silver, and disinfectants?

Wound-Healing:
A Paradigm Shift

For over a century, sterilization has been seen as the best way to prevent infections. Even today, wound care protocols emphasize eliminating bacteria. However, this approach disregards the microbiome and its vital role in healing.

Our skin exists in symbiosis with bacteria that produce fatty acids, vitamins, and other essential metabolites.

Rather than an indiscriminate attack on microbial life, a targeted approach accelerates wound healing.

This principle extends beyond wounds to conditions such as pyoderma, acne, eczema, and UTIs.

Balancing the Microbiome

Bacterial infections arise when the natural balance of the microbiome is disrupted. To restore this balance, Lysando has developed a groundbreaking new class of molecules: Artilysin®s.
These precision-designed molecules reestablish harmony, addressing the root cause of infection.

The Failure of Antibiotics

Resistance

Antibiotics have saved billions of lives–their impact on human health is unparalleled. But their effectiveness is diminishing. Resistant and/or persistent bacteria are on the rise, and deaths from bacterial infections have more than doubled in the past decade.

Despite rigorous testing, no resistance to Artilysin®s has been observed.

Biofilm

Misconceptions persist, such as the idea that all biofilms are harmful. In reality, biofilms – diverse bacterial communities – form protective shields on our skin.

Instead of destroying biofilms indiscriminately, Artilysin®s rebalance their populations, preserving their protective function while eliminating harmful bacteria.

Persistence

Persistent bacteria pose another challenge: they deactivate their metabolism, rendering antibiotics ineffective.

Artilysin®s bypass this entirely, acting like a needle puncturing a balloon – destroying bacteria regardless of their metabolic state.

Intelligent Artilysin® Design

Lysando was among the first in the world to apply AI-driven protein design to microbiome-targeted treatments.

With a proprietary database of over 4,500 constructs and modules, AI enables the rapid development of an infinite number of potential Artilysins. This accelerates time-to-market, ensuring cutting-edge solutions reach patients faster.

Our expert team, specializing in microbiology and protein design, harnesses AI to deliver breakthrough innovations.

Intellectual Property

Lysando is the originator of Artilysin® technology, a disruptive and life-enhancing innovation protected by hundreds of national patents.

AI-driven protein design

Proprietary database

Hundreds of patents

The Team

Contact

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Rethinking Sterilization

Balancing the Microbiome

The Failure of Antibiotics

Intelligent Artilysin® Design

Intellectual Property

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